Verminderd frontaal hersenvolume bij cocaïne-afhankelijke personen die geen behandeling zoeken: verkennen van de rol van impulsiviteit, depressie en roken

Trait impulsivity is commonly associated with cocaine dependence. The few studies that have investigated the relation between trait impulsivity and cortical morphometry, have shown a distinct relation between impulsivity and cortical volume of temporal, frontal and insula cortex. As cortical volume is the function of cortical surface area (SA) and cortical thickness (CT), impulsivity may be differently associated to SA than to CT.The distinct relation between trait impulsivity and cortical morphometry in cocaine users and healthy controls might underlie inefficient control over behavior resulting in maladaptive impulsive behaviour such as cocaine abuse.